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EBOO vs. EBO2: What's the Difference and Which One Does Your Body Actually Need?
- Reboot U
- 50 minutes ago
- 10 min read
Quick Answer: What's the difference between EBOO and EBO2?
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Let us be honest. Most people who walk into a wellness clinic feel like something is off but cannot put their finger on what. Tired all the time. Brain not sharp. Body inflamed.
Conventional testing comes back fine. Supplements help a little. And yet.
What if the problem was not a deficiency you could supplement your way out of, but a burden your blood has been carrying for years?
That is the idea behind ozone blood therapy. And right now, EBOO and EBO2 are the most advanced versions of this approach in existence. They do not just add something to your body. They filter it, oxygenate it, and send it back cleaner than when it left.
Here is what you need to know about both and why EBO2 is the therapy Reboot U in Ocala, FL offers.
First: What Is Ozone Therapy and Why Does It Work?
Ozone is a molecule made of three oxygen atoms (O3). In a medical context, it is used at precise, controlled concentrations to interact with blood, tissues, and pathogens in ways that regular oxygen simply cannot.
When medical ozone contacts blood, a chain reaction begins. Ozone rapidly breaks down into reactive oxygen species and those species do something remarkable. They destroy bacteria, viruses, and fungal cells on contact. They trigger the body's own antioxidant defense pathways. They stimulate immune cells to function more aggressively and efficiently.
This is not fringe science. A 2025 narrative review published in Molecules [1] found that ozone therapy may serve as a valuable adjunct in managing immune dysfunction by modulating cytokine profiles, reducing oxidative stress, and restoring immune homeostasis.
A comprehensive review in the International Journal of Molecular Sciences [2] confirmed that ozone reduces pro-inflammatory cytokines including interleukin 6 across multiple chronic conditions including low back pain, knee osteoarthritis, and rheumatic diseases.
The principle that makes ozone therapy work at a systemic level is called hormesis. A precisely controlled, low dose stressor activates the body's protective and repair systems.
Ozone, used correctly, is exactly that kind of controlled stressor.
What Is EBOO?
EBOO stands for Extracorporeal Blood Oxygenation and Ozonation. It changed what ozone treatment could accomplish. Before EBOO, ozone therapy meant drawing a small amount of blood, mixing it with ozone in a bag, and reinfusing it. That approach worked but had clear limits. You were treating a fraction of your blood volume at a time.
EBOO changed that. In an EBOO session, blood is drawn from one arm, passed through a dialysis style membrane where it is exposed to medical ozone, and returned through the other arm in a continuous loop. No bags. No waiting. The blood is treated while it is still moving.
What happens during an EBOO session:
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Key research published in PMC [3] confirmed that ozone dialysis delivers on average at least three times more therapeutic ozone than other high dose delivery methods including standard autohemotherapy. That makes it significantly more powerful than traditional ozone IV approaches.
EBOO is effective. EBO2 takes everything EBOO does and scales it up considerably. Here is how.
What Is EBO2 and How Does It Go Further?
EBO2 stands for Extracorporeal Blood Oxygenation and Ozonation 2.0. It builds directly on the EBOO framework and then takes it further in three critical ways. This is the therapy Reboot U in Ocala, FL offers.
1. It processes your entire blood volume
EBOO treats roughly 1.8 to 3 liters per session. EBO2 processes 5 to 7 liters, the total blood volume of the average adult. Every red blood cell, every white blood cell, and all of your plasma passes through the filtration and ozone system in a single 60 to 90 minute session. This is not a partial purification. It is a full reset.
2. It adds advanced medical grade filtration
EBO2 includes a filtration step that goes beyond the dialysis membrane in EBOO. This filtration specifically targets and removes oxidized lipids, which are damaged fats that drive inflammation. It also removes inactive proteins linked to autoimmune conditions and cellular debris that accumulates from chronic illness, toxic exposures, and aging. What comes back to your body is not just ozonated. It has been actively cleaned.
3. It adds light therapy through the Hemealumen device
This is the step that makes EBO2 unique. While your blood is being processed, the Hemealumen device exposes it to photobiomodulation, which is light therapy at specific wavelengths. This activates mitochondrial function in your red blood cells, increasing energy output and oxygen carrying capacity before the blood is returned to your body. You are not just getting clean blood back. You are getting energized blood back.
EBOO vs. EBO2: Side by Side
EBOO | EBO2 (at Reboot U Ocala) | |
Full name | Extracorporeal Blood Oxygenation and Ozonation | Extracorporeal Blood Oxygenation and Ozonation 2.0 |
Blood volume treated | 1.8 to 3 liters per session | 5 to 7 liters per session (your entire blood volume) |
Filtration | Dialysis membrane: removes heavy metals, bacteria, fungi | Advanced medical grade filtration: removes oxidized lipids, damaged proteins, toxins, and pathogens |
Light therapy | Not included | Hemealumen photobiomodulation device included |
Ozone delivery | Standard ozone exposure | Precision ozone and oxygen delivery optimized to reduce oxidative stress |
Session length | Approximately 60 minutes | 60 to 90 minutes |
How to think about it | Foundational ozone blood therapy | Next generation, whole body blood purification and cellular reset |
The bottom line: EBOO is powerful. EBO2 is EBOO with the volume turned all the way up plus filtration and light therapy added on top. Reboot U in Ocala, FL offers EBO2 because it delivers the most comprehensive results available.
What Is EBO2 Actually Targeting Inside Your Body?
When we say EBO2 detoxes the blood, we mean something specific. Here is what is being removed, neutralized, or corrected during a session:
Oxidized fats and lipids: Chronic inflammation, poor diet, and metabolic stress cause fats in your blood to oxidize, becoming sticky, pro-inflammatory compounds that coat artery walls, impair circulation, and accelerate aging. EBO2 filtration captures and removes these.
Pathogens: Bacteria, viruses, fungi, and parasites circulating in the bloodstream are neutralized by ozone on contact. This is why EBO2 is commonly used in protocols for chronic Lyme, long COVID, Epstein Barr, and persistent viral infections.
Heavy metals: Lead, mercury, cadmium, and other metals accumulate in the blood over time from environmental exposures including food, water, air, and dental materials. The filtration membrane captures these before blood is returned.
Mold and mycotoxins: Mold exposure is a serious issue throughout Florida, including the Ocala and Marion County area. Mycotoxins disrupt immune function, damage the gut lining, and cause neurological symptoms. EBO2 targets these directly.
Damaged and senescent proteins: Inactive or misfolded proteins are linked to autoimmune dysfunction. EBO2 removes these, reducing the burden that triggers the immune system to attack the body's own tissue.
Inflammatory mediators: Excess cytokines, inflammatory signaling molecules, and oxidative stress compounds that drive chronic systemic inflammation are reduced through both the ozone mechanism and the filtration process.
Who Gets Results with EBO2? Conditions Commonly Supported
EBO2 is used both therapeutically for people managing active conditions and preventively for those focused on longevity, performance, and staying ahead of degenerative trends. The following conditions are most commonly addressed:
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Note: EBO2 is a wellness therapy and is not a treatment or cure for any medical condition. It is used as an adjunct to support the body's natural processes. Always consult your physician about any active medical diagnosis.
Is EBO2 Safe? What You Need to Know Before Your First Session
For most healthy adults and individuals with chronic inflammatory conditions, EBO2 is well tolerated when performed in a professional clinical environment. At Reboot U in Ocala, every client goes through a full intake and health screening before their first session.
The most common responses immediately following a session include improved mental clarity and energy, a deep sense of calm, or mild fatigue as the body processes the changes. All of these resolve within hours.
EBO2 is NOT appropriate for individuals with:
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If you have a complex medical history, our team will review it carefully during your consultation. EBO2 is designed to complement, not replace, your existing care.
How EBO2 Pairs with Other Reboot U Therapies
EBO2 works powerfully on its own. Its results amplify significantly when combined with other therapies in a coordinated protocol. At Reboot U in Ocala, we regularly pair EBO2 with:
IV Nutrient Therapy: After EBO2, your cleaned and oxygenated blood absorbs nutrients with significantly higher efficiency. An IV infusion of glutathione, NAD+, or a Myers Cocktail directly following a session is one of our most popular pairings.
Mild Hyperbaric Oxygen (mHBOT): EBO2 optimizes what is in your blood. mHBOT pressurizes oxygen delivery to tissues that blood alone cannot fully reach. Together they create a comprehensive oxygen optimization protocol at both the vascular and tissue level.
Epigenetic Hair Follicle Testing: Before starting an EBO2 series, we recommend testing. Your epigenetic report reveals heavy metal load, toxin burden, and immune system stress, giving us a precise baseline to measure your results against.
Colon Hydrotherapy: Detox is only as effective as your body's ability to eliminate what has been mobilized. Scheduling a colonic session within a day or two of EBO2 supports rapid removal of the waste the therapy stirs loose.
Red Light Therapy: Light therapy before or after EBO2 extends the mitochondrial activation initiated by the Hemealumen device, compounding the cellular energy benefits of both treatments.
Your Questions Answered
How many EBO2 sessions do I need?
Most clients start with a series of 3 to 6 sessions spaced 7 to 10 days apart to achieve a meaningful baseline shift. Clients managing chronic illness or heavy toxic load may benefit from more. After an initial series, many clients shift to monthly maintenance sessions to sustain results. At Reboot U, your session plan is built around your specific epigenetic data, symptoms, and goals, not a generic schedule.
Will I feel anything during the session?
EBO2 is minimally invasive. You will have two IV lines in place and lie comfortably while the machine does its work. Most clients feel calm, sometimes sleepy, during the session. The majority notice improved energy and mental clarity within 24 to 48 hours. Some experience brief, mild fatigue on the day of treatment, which is a sign the body is processing and adapting.
Is there anything I should do before or after a session?
Arrive well hydrated. Avoid alcohol and heavy meals for at least a few hours beforehand. After your session, drink plenty of water and electrolytes and avoid intense exercise the same day. Colon hydrotherapy within 48 hours is ideal to support elimination. Our team walks you through a full pre and post session protocol during your consultation.
How is EBO2 different from a regular ozone IV?
A standard ozone IV draws 200 to 250 mL of blood, mixes it with ozone in a bag, and reinfuses it. That treats roughly 3 to 5 percent of your blood volume. EBO2 treats your entire blood volume of 5 to 7 liters, with filtration and light therapy added. Published research [3] confirms that ozone dialysis delivers at least three times more therapeutic ozone than standard autohemotherapy. It is not a larger dose of the same thing. It is a fundamentally different class of treatment.
How much does EBO2 cost at Reboot U in Ocala?
Session pricing varies based on the protocol and package selected. We offer single sessions, discounted series packages, and bundled programs that combine EBO2 with IV therapy, hyperbaric oxygen, and other services. Call us at 352-820-3151 or visit rebootocala.com to discuss what fits your goals and budget. Complimentary consultations are available.
Do I need to be sick to benefit from EBO2?
Not at all. A significant portion of our EBO2 clients in Ocala are healthy, high functioning individuals using the therapy as part of a longevity and performance protocol. Athletes use it to accelerate recovery. Biohackers use it to reduce inflammatory load before it becomes symptomatic. Executives use it to maintain cognitive sharpness and immune resilience. You do not need a diagnosis to benefit from clean, oxygenated, optimized blood.
The Bottom Line
Your blood is doing more work than you realize. It is carrying nutrients, oxygen, hormones, and signals. But in most people it is also carrying decades of accumulated toxins, pathogens, damaged proteins, and inflammatory debris that no supplement can touch.
EBOO was a breakthrough. EBO2 is what happens when that breakthrough gets refined, scaled up, and made more powerful.
At Reboot U in Ocala, FL, we offer EBO2 because we are committed to giving you the most advanced, most effective version of every therapy we provide. If you have been dealing with chronic fatigue, inflammation, brain fog, or the lingering effects of mold, Lyme, or viral illness, or if you are simply ready to operate at a higher level, this therapy deserves your attention.
Book a consultation and let us look at your full picture, including your epigenetic test results, before recommending a protocol. Not guesswork. Not generic schedules. Precision wellness built around you.
Ready to find out if EBO2 is right for you?
Book a complimentary consultation at Reboot U in Ocala, FL
352-820-3151 · 1414 SW Martin Luther King Jr Ave, Ocala, FL 34471
Research Citations
The following peer-reviewed sources support the scientific claims in this article. Reboot U provides this content for educational purposes only.
[1] Ozone as an Immunomodulator: New Therapeutic Possibilities in Treatment of Immunodeficiencies. Molecules. 2025; 30(12):1016. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12731440/
[2] de Sire A, et al. Oxygen Ozone Therapy for Reducing Pro-Inflammatory Cytokines in Musculoskeletal Disorders. Int J Mol Sci. 2022;23(5):2528. https://pmc.ncbi.nlm.nih.gov/articles/PMC8910188/
[3] Elvis AM, Ekta JS. Ozone dialysis delivers three or more times the ozone than other forms of ozone blood treatment. PMC. 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC9555023/
[4] Serra MEG, et al. The role of ozone treatment as integrative medicine: an evidence and gap map. Front Public Health. 2023;10:1112296. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885089/
Medical Disclaimer
This article is for educational and informational purposes only. EBO2 is a wellness therapy and is not an FDA cleared treatment for any diagnosed medical condition. Results vary. Always consult a qualified healthcare provider before beginning any new therapeutic protocol. Reboot U team members are health consultants and wellness practitioners, not licensed physicians, and do not diagnose or treat medical conditions.
Reboot U · 1414 SW Martin Luther King Jr Ave, Ocala, FL 34471 · 352-820-3151 · rebootocala@gmail.com
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